Colonic Physiology
نویسندگان
چکیده
The human colon is a dynamic organ, involved in a vast array of functions, including the absorption of water and electrolytes, the salvage of unabsorbed nutrients, and the transport of luminal contents as feces. While not an organ essential for life, the colon still plays a major role in maintaining the overall health of the human body. Understanding these physiologic principles is integral to the successful treatment – both medical and surgical – of colonic disease.
منابع مشابه
Nicotine suppresses hyperexcitability of colonic sensory neurons and visceral hypersensivity in mouse model of colonic inflammation.
Recently, we reported that nicotine in vitro at a low 1-μM concentration suppresses hyperexcitability of colonic dorsal root ganglia (DRG; L(1)-L(2)) neurons in the dextran sodium sulfate (DSS)-induced mouse model of acute colonic inflammation (1). Here we show that multiple action potential firing in colonic DRG neurons persisted at least for 3 wk post-DSS administration while the inflammatory...
متن کاملCholinergic stimulation enhances colonic motor activity, transit, and sensation in humans.
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متن کاملElectrical neuromodulation at acupoint ST36 normalizes impaired colonic motility induced by rectal distension in dogs.
Electroacupuncture (EA) has been shown to improve impaired gastric motility and slow waves in both humans and animals. However, its effects on colonic motility have rarely been investigated. The aim of this study was to investigate the effects and underlying mechanisms of EA on impaired colonic motility induced by rectal distension (RD)in dogs. Colon contractions and transit were measured in va...
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متن کاملEffects of acute graded exercise on human colonic motility.
Whether physical exercise stimulates colonic motility is unclear. Our aim was to determine the immediate effects of graded exercise on colonic motility. Colonic motility was recorded at six sites in 11 untrained subjects, by colonoscopically placing a solid-state probe. Subjects were free to ambulate. The next day, subjects exercised on a bicycle at 25, 50, and 75% of peak oxygen uptake for 15 ...
متن کاملNitrergic regulation of colonic transit in rats.
Nitric oxide has been shown to be an inhibitory neurotransmitter in the mammalian colon, although its role in colonic transit remains unclear. We investigated the effect of the nitric oxide biosynthesis inhibitor NG -nitro-l-arginine methyl ester (l-NAME) on colonic transit in conscious rats. Colonic transit was determined by calculating the geometric center of the distribution of radiochromium...
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تاریخ انتشار 2017